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Prostacyclin and the Mechanism of Action of Antithrombotic Drugs
VIIth International Congress on Thrombosis and Haemostasis
The balance between the proaggregating thromboxane A2 and the antiaggregating prostacyclin forms a homeostatic mechanism for the control of platelet aggregability in vivo. Prostacyclin is a circulating substance released from the lungs which acts by stimulating adenylate cyclase leading to an increase of cyclic AMP in the platelets. The mechanism of antithrombotic action of phosphodiesterase inhibitors like dipyridamole depends on their ability to potentiate the effect of endogenous PGI2.doi:10.1055/s-0039-1684477 fatcat:gcwzp24n35c4ja6rvbptjh7hnu