1918 Journal of the American Medical Association (JAMA)  
During the past thirty years it has been the conclusion of many pathologists who have carefully observed the general configuration of the cadaver at necropsy that the fate of the human body is not a matter of chance but in general is controlled by certain intrinsic physical tendencies that are of congenital origin. This conclusion is merely in line with the doctrine of a constitutional predisposition to disease, the importance of which has been submerged by the advent of the germ theory.
more » ... germ theory. Clinical observers, especially in recent times, have not been so much impressed with the importance of constitutional factors doubtless because the most definite evidences of such tendencies are revealed chiefly at necropsy, and possibly also because the modern clinician is greatly occupied by a multitude of laboratory tests and aids to diagnosis and prognosis, which apply without regard to any constitutional basis of disease.
doi:10.1001/jama.1918.02600450001001 fatcat:e4dos2f3bndcran54rp43emaiq