Microbiological and serological diagnostic tests for Helicobacter pylori: an overview

Y. Glupczynski
1998 British Medical Bulletin  
Different invasive and non-invasive diagnostic tests are available for the diagnosis of H. pylori in the individual patient. In practice, endoscopic tests are best for a primary diagnosis of H. pylori infection because endoscopy allows assessment of treatment indications. The new rapid urease tests may help the clinician in treatment decision-making. Culture is currently not recommended for routine evaluation, but it is becoming increasingly important in certain populations with higher
more » ... e of drug resistance, since it allows testing for susceptibility to antibiotics. Serological testing has been recommended for initial pre-endoscopy or pre-treatment screening in dyspeptic patients. However, several current 'in-office' tests appear insufficiently accurate or would need further validation before being recommended for use in clinical management strategies at a primary care level. The urea breath tests are best suited to confirm eradication early after treatment, while laboratory serology tests are of limited use, since 6 months are required before a result can be obtained. The serological office tests cannot be used for post-treatment assessment of H. pylori status.
doi:10.1093/oxfordjournals.bmb.a011668 pmid:9604441 fatcat:ynrjzfys2ncnzbxngpj4vv4g54