AB0964 The role of mtor gene expression, apoptosis and inflammation in obese patients with knee osteoarthritis

E. Strebkova, E. Chetina, L. Alekseeva
2018 Osteoarthritis   unpublished
effusion. Age, physical exercise, knee osteoarthritis symptoms duration and different anthropometric measurements were collected. Radiographic severity was evaluated according to Kellgren-Lawrence scale. Pain and disability were assessed by WOMAC-pain and WOMAN-function. Calprotectin, TNF-alfa, IL-6 and high-sensitivity C-reactive protein (hs-CRP) were measured by ELISA in synovial fluid. Summary of clinical data and laboratory parameters and their association with WOMAC scales were performed
more » ... ing non-parametric methods. Medians and Spearman correlation (r) were used for continuous measures, and Mann-Whitney test was applied to categorical variables. This study was approved by the local ethics committee. Results: Median higher synovial calprotectin levels were associated with worse WOMAC pain (671.5 vs 431.8 ng/mL, p<0.05).) and function (713.4 vs 400.1 ng/ mL, p<0.05).) scores than patients with inferior levels. Patients with moderate to severe synovial effusion (>8 mm on midline suprapatellar line) had higher calprotectin levels compared with those with mild effusion (626.1 vs 417.5 ng/mL, p<0.05). Synovial calprotectin levels showed moderate correlations with intraarticular TNF-alfa levels (r=0.26), hs-CRP (r=0.27) and a high correlation with synovial IL-6 levels (r=0.53). Conclusions: Calprotectin showed association with inflammatory features as measured by ultrasound and inflammatory markers such as hs-CRP, TNF-alfa and IL-6, and was related to pain and function in patients with knee osteoarthritis with inflammatory features. Calprotectin appears to be a useful marker of inflammation and could be a useful marker for assessing response to treatments targeting inflammation.
doi:10.1136/annrheumdis-2018-eular.5055 fatcat:vvrrzitrmnhsrfmainbzlgu2y4