The effects of polyherbal formulations were studied in the streptozotocin-nicotinamide (STZ-NA) induced diabetes rat model. The present study was undertaken to assess the effects of polyherbal formulations on the blood sugar level (BSL) as well as blood lipid level(BLL) of STZ-NA diabetic rats. The leaves of Moringa oleifera and roots of Raphanus raphanistrum were used for the study due to the presence of various phytoconstituents such as alkaloids, saponins, tannins, steroids, phenolic acids,

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... lavonoids. Three polyherbal formulations were prepared from different portions of leaves of Moringa oleifera and roots of Raphanus raphanistrum and titled PHF-I, PHF-II and PHF-III. Diabetes in experimental animals was induced by STZ injection intraperitoneally (i. p) after 30 min of Nicotinamide injection i. p in all animal groups except normal control group animals. Group, I served as normal control received no treatment. Group II served as negative control received streptozotocin-nicotinamide. Group III rats were treated with Metformin, Group IV, Group V and Group VI rats treated with PHF-I, PHF-II and PHF-III respectively. Physical parameters (body weight, feed and water intake), Biochemical parameters (Blood Glucose, Serum Insulin, Serum C-Peptide Level, Serum Leptin, Serum Total cholesterol, Serum Triglycerides, LDL and VLDL) were measured on 0th, 14th and 28th day. The study results and histopathology of the pancreas indicate that oral administration of polyherbal formulation- II proved as a more effective, safe anti-diabetic agent in comparison to Polyherbal formulation I and III by Decrease in body weight, fasting blood glucose, serum glucose level. Increase in serum insulin level, serum C-peptide with a significant decrease in blood serum lipid level.