and Purpose-Perfusion-weighted magnetic resonance imaging (PWI) is a reliable and semiquantitative method for estimating cerebral hemodynamics. We sought to evaluate the potential of PWI for assessing cerebral blood flow (CBF) and metabolism compared with positron emission tomography (PET) in patients with chronic occlusive carotid disease. Methods-In 24 patients with chronic unilateral occlusive carotid disease, time-to-peak (TTP) delay (TTP-D) measured by PWI was compared with CBF, cerebral

more »

... ood volume (CBV), and oxygen extraction fraction (OEF) obtained by PET. TTP indicates the time from the start of PWI to the bolus peak. TTP-D indicates the difference in TTP values between the occlusive and contralateral hemispheres. TTP-D was compared between patients with normal and reduced CBF/CBV and also between patients with normal and elevated OEF. Results-TTP-D in patients with reduced CBF/CBV was significantly longer than that in patients with normal CBF/CBV (3.4Ϯ1.8 versus 1.4Ϯ0.7 seconds; PϽ0.001). In the patients with reduced CBF/CBV, TTP-D correlated with OEF significantly (rϭ0.710, PϽ0.0001). TTP-D in patients with elevated OEF was significantly longer than that in patients with normal OEF (4.8Ϯ2.2 versus 2.0Ϯ0.9 seconds; PϽ0.01). In all 5 patients with TTP-D Ն4 seconds, OEF was elevated markedly. Conclusions-TTP-D Ն4 seconds is considered to indicate a high risk of hemodynamic failure. The measurement of TTP-D by PWI appears to provide important clinical information for evaluating cerebral hemodynamics in chronic occlusive carotid disease. (Stroke. 2003;34:1662-1666.)