Drug repurposing approaches to fight Dengue virus infection and related diseases

Marco Radi
2018 Frontiers in Bioscience  
Shortcuts for Dengue treatment 998 © 1996-2018 ABSTRACT Dengue is a mosquito-borne viral disease caused by four antigenically distinct serotypes of Dengue Virus (DENV), namely DENV1-4 and is currently considered the most important arthropodborn viral disease in the world. An effective antiviral therapy to treat Dengue Virus infection is still missing and a number of replicative cycle inhibitors are currently under study. Considering the rapid spreading of DENV and the common timeframe required
more » ... timeframe required for bringing a new drug on the market, the repurposing of approved drugs used for different diseases to identify novel inhibitors of this pathogen represents an attractive approach for a rapid therapeutic intervention. Herein, we will describe the most recent drug repurposing approaches to fight DENV infection and their implications in antiviral drug-discovery. Stevens, M.E. Gahan, S. Mahalingam, P.A. Keller: The medicinal chemistry of dengue fever.
doi:10.2741/4630 pmid:28930586 fatcat:3gxfzywzdzcnxk236wguu4bumu