4H-1,4-Benzothiazines and its derivatives are potential pharmacologically and industrially useful agents. They were prepared by condensation followed by oxidative cyclization of 2-amino-4,6-dimethylbenzenethiol with varied βdiketones/β-ketoesters in dimethyl sulfoxide. On refluxing with H 2 O 2 in glacial acetic acid, the substituted 4H-1,4-Benzothiazines yielded 4H-1,4-Benzothiazine-1,1-dioxides (sulfones). These compounds were evaluated for antioxidant activity by DPPH and ABTS assay and the

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... ntimicrobial properties were investigated against various strains of bacteria (Coagulase negative Staphylococci, Coagulase positive Staphylococci, Enterobacter) and fungi (Candida albicans) using Paper disc method. The structures of the compounds have been confirmed by spectral and elemental analysis.