Chronic Obstructive Pulmonary Disease (COPD) is the fourth leading cause of death in the world. COPD exacerbations constitute a significant burden on patients and healthcare systems. A study on 'Bacteriological profile of Chronic Obstructive Pulmonary disease' was conducted in the Department of Microbiology at Government medical college, Ernakulam for a period of 1 year from 1/3/2016 to 28/2/2017.Out of 105 sputum samples tested, 24 of 49 mucopurulent samples (49%) and 13 of 21 purulent samples

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... (62%) were culture positive for pathogenic bacteria. The most common bacteria isolated was Pseudomonas aeruginosa (35%) followed by Acinetobacter species (20%), Hemophilus influenzae (17.5%), E.coli (10%), Klebsiella species (7.5%), Staphylococcus aureus (7.5%) Stenotrophomonas maltophilia (2.5%). Multi drug resistant bacteria comprised of 40% of the isolates. The mortality rate was 15 % among culture positive patients.