Multicomponent Materials to Improve Solubility: Eutectics of Drug Aminoglutethimide

Basanta Saikia, Andreas Seidel-Morgenstern, Heike Lorenz
2021 Crystals  
Here, we report the synthesis and experimental characterization of three drug-drug eutectic mixtures of drug aminoglutethimide (AMG) with caffeine (CAF), nicotinamide (NIC) and ethenzamide (ZMD). The eutectic mixtures i.e., AMG-CAF (1:0.4, molar ratio), AMG-NIC (1:1.9, molar ratio) and AMG-ZMD (1:1.4, molar ratio) demonstrate significant melting point depressions ranging from 99.2 to 127.2 °C compared to the melting point of the drug AMG (151 °C) and also show moderately higher aqueous
more » ... ies than that of the AMG. The results presented include the determination of the binary melt phase diagrams and accompanying analytical characterization via X-ray powder diffraction, FT-IR spectroscopy and scanning electron microscopy.
doi:10.3390/cryst12010040 fatcat:gzvpxza6pfarbixx64wpqpidci