Invasive Mole - Case Report of Massive Uterine Destruction

Branka Nikolić, Jelena Lazić, Snežana Rakić, Svetlana Dragojević-Dikić, Aleksandar Ćurković, Vesna Lacković
2008 Bosnian Journal of Basic Medical Sciences  
Patient with malignant Gestational Trophoblastic Neoplasm (GTN) was treated by mean of MTX-FA, MAC, EMA-CO and EMA-EP. Changes in serum human chorionic gonadotropine (beta hCG) levels and changes in ultrasonographic fi ndings were checked weekly. Finally transabdominal hysterectomy with ovaries conservation was done and polychemotherapy administrated after the operation until three consecutive serum chorionic gonadotropine values were negative. Th is is a case report of Invasive mole in 
more » ... ive mole in  years old patient without possibillity to preserve reproductive health. GTN developed two months after spontaneous abortion in th week gestation. No changes in uterine structure were found during the fi rst ultrasonographic examination. Th ree months after abortion and one month after GTN confi rmed, massive destruction of lateral uterine wall was detected during transvaginal Doppler ultrasound examination. Resistance index of , was significantly lower than normal, with hypervascularisation in aff ected tissue. Serum beta hCG confi rmed poor eff ect of polychemotherapy treatment and decision for operative treatment was made. Hystological fi ndings after the operation confi rmed malignant GTN-invasive mole. Specifi c changes in ultrasonographic picture could have an impact in therapy making decision and could not be refereed without the most relevant parameter such is serum human chorionic gonadotropine. KEY WORDS: gestational trophoblastic neoplasm, human chorionic gonadotropine, resistance index, transvaginal Doppler ultrasonography.
doi:10.17305/bjbms.2008.2900 pmid:19125711 fatcat:pmtlm5ckbzel7kmdqipczjbsti