The occurrence of Alyssum desertorum, a species belonging to A. sect. Alyssum, is reported for the first time in Italy. It was found in Abruzzo (central Italy) in the territory of National Park of Gran Sasso and Laga mountains and surrounding areas. Morphological similarities with the other taxa recorded in Italy belonging to A. sect. Alyssum are briefly discussed. Information about the typification of the name, habitat, phenology and distribution in Italy are also provided.