An Approach to Oral Controlled Drug Delivery: Floating Drug Delivery System

Punit Gupta, Pavin Yadav, Kapil Soni, Jitendra Kumawat
2013 unpublished
The oral route is increasingly being used for the delivery of therapeutic agents because the low cost of the therapy and ease of administration lead to high levels of patient compliance. More than 50% of the drug delivery systems available in the market are oral drug delivery systems. Technological attempts have been made in the research and development of rate-controlled oral drug delivery systems to overcome physiological adversities, such as short gastric residence times (GRT) and
more » ... GRT) and unpredictable gastric emptying times (GET). It is known that differences in gastric physiology, such as, gastric pH, and motility exhibit both intra-as well as inter-subject variability demonstrating significant impact on gastric retention time and drug delivery behavior. Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), swelling and expanding systems, polymeric bioadhesive systems, high-density systems, modified-shape systems and other delayed gastric emptying devices. In this review, current & recent developments of Stomach Specific FDDS are discussed. The present review addresses briefly about the floating drug delivery systems. Introduction Floating systems or Hydrodynamically controlled systems are low-density systems that have sufficient buoyancy to float over the gastric contents and remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. While the system is floating on the gastric contents, the drug is released slowly at the desired rate from the system 1,2. Gastro retentive systems can remain in the gastric region for several hours and hence significantly prolong the gastric residence time of drugs. Prolonged gastric retention improves bioavailability, reduces drug waste, and improves solubility for drugs that are less soluble in a high pH environment. It has applications also for local drug delivery to the stomach and proximal small intestines. Gastro retention helps to provide better availability of new products with new therapeutic possibilities and substantial benefits for patients. To successfully modulate the gastrointestinal transit time of a drug delivery system through floating drug delivery system (FDDS) For maximal gastrointestinal absorption of drugs and site-specific delivery, one needs to have a good fundamental understanding of the anatomic and physiological characteristics of the human GIT 3,4. The controlled gastric retention of solid dosage forms may be achieved by the mechanisms of mucoadhesion, flotation, sedimentation, expansion modified shape systems or by the simultaneous administration of pharmacological agent that delay gastric emptying 5. Factors Affecting Gastric Residence Time of FDDS 1. Density of tablets Density is the main factor affecting the gastric residence time of dosage form. A buoyant dosage form having a density less than that of the gastric fluids floats, since it is away from the pyloric sphincter, the dosage unit is retained in the stomach for a prolonged period. A density of less than 1.0g/ml i.e. less than that of gastric contents has been reported. However, the floating force kinetics of such dosage form has shown that the bulk density of a dosage form is not the most appropriate parameter for describing its buoyancy capabilities 1,2. 2. Size of tablets Retention of floating dosage forms in stomach depends on the size of tablets. Small tablets are emptied from the stomach during the digestive phase, but large ones are expelled during the house keeping waves.