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Platelets supply p38 MAPK signaling that licenses pro-inflammatory cytokine responses of human monocytes
[article]
2022
bioRxiv
pre-print
ABSTRACTClassical CD14+ monocytes are the predominant monocyte population in human blood. They are primarily engaged in host defense programs and secrete pro-inflammatory cytokines that orchestrate immune responses. While aberrant monocyte activity elicits cytokine storms, dysfunctional monocytes are associated with immunoparalysis, an equally life-threatening state of immunosuppression observed in severe sepsis, trauma, or respiratory viral infections. Hence, unraveling the mechanisms
doi:10.1101/2022.08.10.503291
fatcat:daxiczkrfratvleqx5mca6rpou