The growing demand for Internet of Things (IoT) applications in agribusiness increases the necessity of reliable and secure connectivity in rural areas. Thus, in the particular case of Brazil, some initiatives aim to take advantage of frequency bands dedicated to limited private services. For instance, cellular networks based on orthogonal frequency-division multiple access (OFDMA) in 250 MHz bands require specialized adaptations because the interference between cells increases when these

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... s operate in the Very High Frequency (VHF) band. This work presents an analysis based on a reliable simulation of interference mitigation in OFDMA systems at 250 MHz using a network simulator. The simulator is calibrated with data obtained in the field by an extensive and rigorous drive test. Therefore, the analysis is based on a comparison of traditional frequency reuse schemes with a machine learning approach based on deep reinforcement learning (DRL) to reduce inter-cell interference. The numerical results indicate that the DRL approach outperforms the traditional frequency reuse (FR) schemes in four different typical agribusiness scenarios. INDEX TERMS Frequency reuse, Internet of Things, deep reinforcement learning, customized cellular networks, 250 MHz.