T-Rapa6 and T-Rapa12 Cells Differentially Mediate Acute Gvhd after Low-Intensity Allogeneic HCT

David Halverson, Scott Rowley, Brenna Hansen, Bazetta Blacklock Schuver, Miriam Mossoba, Seth Steinberg, Fran Hakim, Roger Kurlander, Juan Gea-Banacloche, Claude Sportes, Nancy Hardy, Dennis Hickstein (+14 others)
2014 Biology of Blood and Marrow Transplantation  
with [ 18 F]FHBG, we detected CD34-TK75+ human T cells in the thymus and lymph nodes only in mice that developed GvHD. Summary: This "first-in-man" study demonstrated the safety and feasibility of manufacturing both CD34-TK75+ T cells and [ 18 F]FHBG onsite for administration to patients. A future upfront haploidentical transplant study will employ 100-fold more CD34-TK75 modified T cells.
doi:10.1016/j.bbmt.2013.12.199 fatcat:a73xowmjsjbjddztetyz4pjtma