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Integrated skin sensitization assessment based on OECD methods (I): Deriving a point of departure for risk assessment
2022
Three guidelines covering key events in the skin sensitization adverse outcome pathway are endorsed by the Organisation for Economic Co-operation and Development (OECD). A recent guideline covers Defined Approaches (DA) to combine data from these tests for regulatory (sub)-classification. These methods provide continuous data that could characterize the sensitization potency on a more granular scale beyond (sub)-classifications. We assembled a comprehensive database on in vitro and in vivo
doi:10.14573/altex.2201141
pmid:35404469
fatcat:w3pmvol355ds3gnkjczenx5vpe