Twenty-first century skills are significant factors to consider and develop for the learners in the K to 12 curriculum.These twenty-first century skills include digital-age literacy, inventive thinking, effective communication and high productivity. This study is a descriptive, developmental and evaluative type of research. Survey study conducted among Secondary Biology teachers in private and public shools in urban and rural schools. The main objectives of the study are to determine the

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... g twenty first century skills of the Secondary Biology teachersin private and public secondary schools and to be able to develop a twenty first century module for the enhanced basic education. Based on the result, digital-age literacy is the domain with the least computed mean followed by effective communication while inventive thinking and high productivity have the highest computed mean value which are the common practices of private and public secondary schools. With the evaluation of the twenty-first century skills through survey study, the researcher was able to design and prepare instructional modules for the development of twenty first century skills in teaching Biology for Grade 7 to 10 using ABC-TEACH Model. The developed twenty first century instructional modules in teaching Biology would help the teachers to enhance and improve the quality of teaching Biology would help teachers to enhance and improve the quality of teaching to be delivered to the learners particularly in the field of Biology. Likewise, the learners would be engaged and would enhanced their twenty first century skills specifically digital-age literacy, inventive thinking, effective communication and high productivity. These skills would fully developed upon completion of the various activities, drills, worksheets, exercises and other tasks given in the instructional modules of Grade 7,8,9 and 10.