trum, solely on the basis of in vitro results. The results of Kaye et al. suggest that these newer antibiotics, despite the claims, may not offer improved in vivo results against Streptococcus species. Because of this possibility, caution seems advisable when using monotherapy for any serious bacterial corneal ulcer. Instead, I prefer a topical fluoroquinolone (whichever agent) plus topical fortified gentamicin (13.6 mg/mL).