In this paper we present a method for in vivo surface reconstruction and 3D vessels segmentation from Speckle-Variance Optical Coherence Tomography imaging, applied to dermatology. This novel technology allows us to capture motion underneath the skin surface revealing the presence of blood vessels. Standard OCT visualization techniques are inappropriate for this new source of information, that is crucial in early skin cancer diagnosis. We investigate 3D reconstruction techniques for better

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... lization of both the external and internal structure of skin lesions, as a tool to help clinicians in the task of qualitative tumor evaluation.