An Electronically Controlled Microfluidic Approach towards Artificial Cells

Uwe Tangen, Patrick F. Wagler, Steffen Chemnitz, Goran Goranovic, Thomas Maeke, John S. McCaskill
2006 ComPlexUs  
This work focuses on the application of on-line programmable microfl uidic bioprocessing as a complementation vehicle towards the design of artifi cial cells. The electronically controlled collection, separation and channel transfer of the biomolecules are monitored by a sensitive fl uorescence setup. Two different physical effects, electrophoresis and electroosmotic fl ow, are used to allow for a detailed micro-control of fl uids in micro-reaction environments. A combination of these two basic
more » ... of these two basic electronically controlled input reaction chambers makes com-binatorial fl uidic networks and indefinitely sustained biochemical or chemical reaction networks feasible. Experimental data showing the power of this approach is presented. Not only does this processing power pave the way towards the development of artifi cial cells (using a technology to complement not yet established autonomous metabolic or replication capabilities) but it also opens up new processes for applications of combinatorial chemistry and lab-on-a-chip biotechnology to drug discovery and diagnosis.
doi:10.1159/000094187 fatcat:rvlklgxipbeihe3fazvcgct7pi