Neoadjuvant Chemotherapy Using Platinum-Based Regimens for Stage Ib2-II Squamous Cell Carcinoma and Non-Squamous Cell Carcinoma of the Cervix [chapter]

Tadahiro Shoji, Eriko Takatori, Hideo Omi, Masahiro Kagabu, Tastuya Honda, Yuichi Morohara, Seisuke Kumagai, Fumiharu Miura, Satoshi Takeuchi, Akira Yoshizaki, Toru Sugiyam
2012 Squamous Cell Carcinoma  
All 43 were scheduled to undergo a radical hysterectomy, including 23 with squamous cell carcinoma and 20 with non-squamous cell carcinoma. Inclusion criteria The following set of inclusion criteria was employed for selection of study subjects. (1) Histologically verified squamous cell carcinoma or non-squamous cell carcinoma of the uterine cervix; (2) locally advanced stage Ib2 to IIb; (3) age: 20 years upward and less than 70 years; (4) Eastern Cooperative Oncology Group (ECOG) performance
more » ... COG) performance status (PS): 0-2; (5) initially treated case; (6) the presence of an MRI-measurable bulky mass in the uterine cervix; (7) hematologic and blood biochemical findings meeting the following criteria [WBC count  4,000/mm 3 ; neutrophil count  2,000/mm 3 ; platelet count  100,000/mm 3 ; hemoglobin 10.0 g/dl ; AST and ALT levels  2 times the upper limit of normal reference range at study site ; serum total bilirubin level 1.5 mg/dl ; serum creatinine 1.5 mg/dl ; and creatinine clearance 60 ml/min]; (8)life expectancy 6 months; and (9) written informed consent personally given by the subject.
doi:10.5772/23214 fatcat:iri245lakvdthjt5nwufpqzhx4