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Convincing indings from animal and clinical studies have shown that exercise improves mood and cognition in addition to cardiovascular and metabolic beneits. Exercise, with the greatest efects on the hippocampus, which has a central role in learning and memory, increases neurogenesis and synaptic plasticity. "lthough the exact molecular mechanisms responsible for the exercise-induced neuroplasticity need to be clariied, some neurotrophic and angiogenic factors e.g. "DNF, IGF-, bFGF2 and VEGFdoi:10.5772/64801 fatcat:tp2xspponjdedhxpetdhpcg3de