Long-term Remission of Primary Gastric T Cell Lymphoma Associated with Human T Lymphotropic Virus Type 1: A Report of Two Cases and Review of the Literature

Keiichi Tanaka, Shotaro Nakamura, Takayuki Matsumoto, Katsuya Hirakawa, Ritsuko Yanaru-Fujisawa, Kaoru Onoyama, Hisanobu Sakata, Koichi Ohshima, Takashi Yao, Mitsuo Iida
2007 Internal medicine (Tokyo. 1992)  
Two cases of primary gastric T-cell lymphoma associated with human T lymphotropic virus type 1 (HTLV-1) are presented. Case 1 was a 54-year-old man who had multiple ulcerating tumors in the lower corpus and gastric antrum. Case 2, a 60-year-old man, showed a large ulcerating tumor in the upper corpus. Both patients were positive for serum anti-HTLV-1 antibody and for the monoclonal integration of HTLV-1 proviral DNA in the tumor cells by Southern blot analysis. The patients were thus diagnosed
more » ... ere thus diagnosed as having primary gastric T-cell lymphoma associated with HTLV-1 of stage II1. Case 1 underwent total gastrectomy followed by chemotherapy, while Case 2 was treated by chemotherapy and radiotherapy. Both patients have been in complete remission for more than 4 years (96 months in Case 1 and 50 months in Case 2) after the treatments. Although primary gastric T-cell lymphomas associated with HTLV-1 is characterized by an extremely poor prognosis, the present cases suggest that in the early stage, long-term survival can possibly be achieved with appropriate treatments.
doi:10.2169/internalmedicine.46.0323 pmid:17978535 fatcat:7ssp4msio5cnrfboqo2itx6o4q