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Extractive Spectrophotometric Method for the Determination of Some Antipsychotic Drugs Using Eriochrome Black T
Journal of Applied Pharmaceutical Science
Simple, accurate, precise, and rapid extractive spectrophotometric method was developed for the determination of four antipsychotics drugs, namely sulpiride (SUP), olanzapine (OLP), clozapine (CLP) and aripiprazole (ARP) both in tablets and in biological fluids. The method was based on the formation of red colored ion-pair complex between the studied drugs and eriochrome black T (EBT) with absorption maxima at 514 nm. The stoichiometry of the complexes in either case was found to be 1: 1 anddoi:10.7324/japs.2015.50605 fatcat:td3najtvq5hkxbvlaycicunmw4