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NADPH consumption by L-cystine reduction creates a metabolic vulnerability upon glucose deprivation
[article]
2019
bioRxiv
pre-print
The consequences of metabolic reprogramming in cancer can include an increased dependence on metabolic substrates such as glucose for survival. As such, the vulnerability of cancer cells to glucose deprivation creates an attractive opportunity for therapeutic intervention. Because it is not possible to starve tumors of glucose in vivo, we sought to identify the mechanisms regulating cancer cell death upon glucose deprivation and then design combinations of inhibitors to mimic glucose
doi:10.1101/733162
fatcat:owpwow5355blna75o3bq5u5dui