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The accurate prediction and characterization of DNA melting domains by computational tools could facilitate a broad range of biological applications. However, no algorithm for melting domain prediction has been available until now. The main challenges include the difficulty of mathematically mapping a qualitative description of DNA melting domains to quantitative statistical mechanics models, as well as the absence of 'gold standards' and a need for generality. In this paper, we introduce a newdoi:10.1088/0953-8984/21/3/034109 pmid:21817254 fatcat:wtl4ddqynzefzpows2cwvh7iqu