P114 Implications of NICE 2016 tuberculosis guidance for a TB contact screening service

AM Ray, S Oglesby, C Mullarkey, JP Watson
2016 Thorax  
Results 181 patients (M:F 87:94; age range 11-83; average age 44.8 years) had received at least one dose anti-TNF and were included in this study (see Table) . The majority of patients had colitis (n = 143; 79%). 52 patients (28.7%) did not have a documented QFT or IGRA (interferon gamma release assay) result. LTBI was diagnosed in 8 (6.2%) with reactive QFT of whom 7 completed chemoprophylaxis and 1 was referred for further investigation and treatment elsewhere. 95 (73.6%) were QFT
more » ... ere QFT non-reactive. 26 (20.2%) were QFT indeterminate, all of whom had a diagnosis of colitis. Colitis patients were more likely to be QFT indeterminate if they were tested at the time of rescue anti-TNF with or without surgery (RR 5.71; 95% CI: 2.49-13.09; p < 0.0001). 2 patients who received rescue anti-TNF and were subsequently found to be QFT reactive, successfully completed LTBI chemoprophylaxis.
doi:10.1136/thoraxjnl-2016-209333.257 fatcat:gc23zxd7frem7nekntuygsdf7i