Assessment of Prothrombin Time, Activated Partial Thromboplastic Time Platelets Count and Serum Alpha Amylase in Acute Pancreatitis Sudanese Patients

Amna Siddig Hamdan Obied, Dr. Amira Ahmed Khalid Humeida
2017 IOSR Journal of Dental and Medical Sciences  
Acute pancreatitis is a sudden inflammation that lasts for a short time. It may range from mild discomfort to a severe, life-threatening illness.Acute pancreatitis (AP) is a potentially lethal disorder with no specific medical treatment. AP is characterized by a spectrum of symptoms, ranging from a local inflammatory process to more severe form (acute necrotizing pancreatitis). In addition, pancreatitis may be further classified into acute interstitial and acute hemorrhagic disease. In the
more » ... isease. In the first type, the gland architecture is preserved but is edematous. Inflammatory cells and interstitial oedema are prominent within the parenchyma. Haemorrhagic disease is characterized by marked necrosis, haemorrhage of the tissue, and fat necrosis . There is marked pancreatic necrosis along with vascular inflammation and thrombosis. Severe acute pancreatitis may cause dehydration and low blood pressure. The heart, lungs, or kidneys may fail and if bleeding occurs in the pancreas, shock and even death may follow . Objective: The purpose of this study was to assess of Prothrombin Time, Activated Partial Thromboplastic Time, Platelets count and serum amylase in acute pancreatitis Sudanese patients. Materials and Methods: This study a case control study , that included Sixty samples to assess Prothrombin Time(PT) , Activated Partial Thromboplastic Time(APTT) , Platelets countand serum amylase in acute pancreatitis Sudanese patients. 30 samples were collected from patients (case group) and 30 samples were collected from healthy persons which represented the control group.This study was approved by ethical committee of ministry of health, and informed consent was obtained from each participant before sample collection.Data was be collected by a structured questionnaire system from patients inIbnSenahospital. The PT ,APTT was done by semi-automated coagulometer (COATRON-MI) and platelate by using Sysmex Kx-21N.the data analyzed using SPSS21. Results: In this study the mean± SD of age PT, PTT and Platelets in case group were59.33 (± 7.36), 31.06 (± 6.29) seconds, 57.33 (± 9.20)seconds and 306.53 (± 60.44)x10 9 /µL respectively, While the mean± SD of PT, PTT and Platelets in control group were 13.33 (±1.15)seconds , 34.94 (± 2.59)seconds and 287.43 (± 47.59)x10 9 /µLrespectively.the difference was statistically significant (P=0.00) Conclusion: This study concluded that PT and APTT were prolonged in patients with acute pancreatitis compared to the normal subjects and Platelets count was within normal range in all patients.
doi:10.9790/0853-1605070509 fatcat:swzyrrb2gbgsjioefpjwvosufi