In this paper, we examine the consistency of the Large Hadron Collider (LHC) data collected during Run 1 and 2 by the ATLAS and CMS experiments with the predictions of a 2-Higgs Doublet Model (2HDM) embedding Vector-Like Quarks (VLQs) for pp → H,A production and H,A→γγ decay mechanisms, respectively, of (nearly) degenerate CP-even (H) and CP-odd (A) Higgs bosons. We show that a scenario containing one single VLQ with Electro-Magnetic (EM) charge 2/3 can explain the above ATLAS and CMS data for

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... asses in the region 350 GeV ≤ m_ VLQ≤ 1.5 TeV or so, depending on tanβ, and for several values of the mixing angle between the top quark (t) and its VLQ counterpart (T).We then perform a global fit onto the model by including all relevant experimental as well as theoretical constraints. The surviving samples of our analysis are discussed within 2σ of the LHC measurements. Additionally, we also comment on the recent anomalous result reported by CMS using Run 2 data on the associated Standard Model (SM) Higgs boson production with top quark pairs pp→ tt̅h with an observed significance of 3.3σ. Other than these specific examples, we also present a phenomenological analysis of the main features of the model, including the most promising T decay channels.