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Using evolutionary computations to understand the design and evolution of gene and cell regulatory networks
2013
Methods
This paper surveys modeling approaches for studying the evolution of gene regulatory networks (GRNs). Modeling of the design or 'wiring' of GRNs has become increasingly common in developmental and medical biology, as a means of quantifying gene-gene interactions, the response to perturbations, and the overall dynamic motifs of networks. Drawing from developments in GRN 'design' modeling, a number of groups are now using simulations to study how GRNs evolve, both for comparative genomics and to
doi:10.1016/j.ymeth.2013.05.013
pmid:23726941
pmcid:PMC3743956
fatcat:fec6itwwbnd6zpiude23du6i44