Current and future antenatal management of isolated congenital diaphragmatic hernia

Francesca Maria Russo, Paolo De Coppi, Karel Allegaert, Jaan Toelen, Lennart van der Veeken, George Attilakos, Mary Patrice Eastwood, Anna Louise David, Jan Deprest
2017 Seminars in Fetal & Neonatal Medicine  
Congenital Diaphragmatic Hernia (CDH) is surgically correctable, yet the poor lung development determines mortality and morbidity. In isolated cases the outcome can be predicted prenatally by medical imaging. Cases with a poor prognosis could be treated before birth. Prenatal modulation of lung development however remains experimental. Fetoscopic Endoluminal Tracheal Occlusion triggers lung growth and is currently being evaluated in a global clinical trial (www.totaltrial.eu). Prenatal
more » ... ental sildenafil administration may in due course be a therapeutic approach, reducing the occurrence of persistent pulmonary hypertension, either alone or in combination with fetal surgery.
doi:10.1016/j.siny.2017.11.002 pmid:29169875 fatcat:zdua2p73wrfgvmwtgepacrzlxq