Two cases of neural tube defects with dolutegravir use at conception in south Brazil

Regis Kreitchmann, Fernando Rocha de Oliveira, Eduardo Sprinz
2021 Brazilian Journal of Infectious Diseases  
Dolutegravir (DTG) is amongst the most prescribed antiretrovirals worldwide and is recommended as first line regimen in most HIV treatment guidelines. Its use, although infrequently, had been associated to an increased chance of neural tube defects (NTD) in Botswana, Africa. Herein we describe two cases of NTD in women who conceived while taking DTG as part of their antiretroviral treatment in the city of Porto Alegre, Brazil.
doi:10.1016/j.bjid.2021.101572 pmid:33852885 fatcat:3dseva735javrmvftqtwxdr7si