and Aims: EBV is a human herpesvirus that infects more than 90% of the world's population. Although, benign and asymptomatic in most cases, the infection can cause many nonmalignant and malignant disorders of lymphoid and epithelial origins. The objective of this study was detected in IM prevalence in Neyshabur, Northeast Iran from 2010-2014. Materials and Methods: This cross-sectional descriptive epidemiological survey was performed in Neyshabur between 2010 and 2014 to reveal the prevalence

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... infectious mononucleosis. A total of 114 patients were studied. Briefly, patients with a positive test for specific IgG and IgM were determined as positive cases. Results: the overall prevalence of IM was 14%. The mean age±SD for infectious mono test is 18.96± 15.79. the age groups of 0-10 and 21-30 years old, were the most positive cases in this period. In addition, 31-40 and upper 50 years were not positive cases. Male patients were significantly more positive and likewise, it was observed that the spring and summer seasons had significantly higher positive cases of IM. Among the five years of this study, it was a decreasing status from 2010 (23.1%) to 2014 (9.1%), although a slight fluctuation was occurring. Conclusions: the prevalence of IM was low in Neyshabur city. Moreover, children and male patients had relatively higher prevalence of the disease. Furthermore, it was observed a higher rate of IM in the spring and summer seasons.