Liquid-phase synthesis of N,N'-diacetyl-β-chitobiosyl allosamizoline

H.-L Huang, F Liu, J Chen, G.-L Huang
2014 Bulgarian Chemical Communications   unpublished
Liquid-phase synthesis of N,N'-diacetyl-β-chitobiosyl allosamizoline 2 was studied. The N-benzyloxycarbonyl (Cbz) protected trichloroacetimidate donors 3 and 5 were prepared according to the routine method. The target allosamidin analogue 2 was high-efficiently synthesized by iterative glycosylation reactions, catalytic hydrogenation, acetylation, and deacetylation, respectively.
fatcat:37pjrulihzhkpaivtkvhlhybbi