Differential expression of PRELP in amyotrophic lateral sclerosis [post]

Shahan Mamoor
2022 unpublished
Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of PRELP, encoding proline- and arginine-rich end leucine rich
more » ... peat protein, in induced pluripotent stem cell (iPSC)-derived motor neurons of patients with ALS. PRELP was also differentially expressed in primary motor neurons isolated from patients with ALS. PRELP transcript was present at significantly lower levels in ALS iPSC-derived motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
doi:10.31219/osf.io/5ubtv fatcat:nn527bhirzedjgciqs4mpxy6am