Among the an bacterial agents used in various inflammatory skin diseases, sulfonamides in the treatment of Wegener's granulomatosis, and tetracyclines for inflammatory acne; the la er were first assessed in 1968 ABSTRACT Background: Obviously, an bacterial agents are primarily directed against bacteria. However, because microorganisms can ini ate an exaggerated inflammatory reac on, and as pathogens which persist in cryp c reservoirs (cells or granuloma ssue) can be the underlying cause of

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... ic inflamma on, the hypothesis that an bacterials can down regulate inflamma on. Methodology: Healthy adult mice weighing 20 -30 g and aged 6-8 weeks, each group 6 mice were included. 1% carrageenan administered to produce inflamma on. Grouping: Group 1: Normal saline 0.2 ml. i.p., Group 2: Diclofenac sodium 25mg/kg, Group 3 Ciprofloxacin 50 mg/kg, Group 4: Azithromycin 20mg/kg. Drugs were administered Intra Peritoneal. A er 30 min of test drugs administra on each group of mice were received subplantar administra on of 0.05ml of saline (Control) or 0.05ml carrageenan (1%) for test groups 2 to 4. Paw volumes were measured by dipping in to the mercury plethysmograph at 30, 60, 120 and 180 minutes and results were tabulated. Results: Diclofenac, ciproflaoxin, Azithromycin inhibited paw edema in % at 30min 42. 85, 28.55, 14.28, at 60min 75, 50, 25, at 120min 71.42, 42.85, 14.28, and at 180 min 50, 50, 25 respec vely. Conclusion: Ciprofloxacin (50mg/kg) has exhibited consistent an -inflammatory, but the an -inflammatory ac vity of is less than that of Diclofenac sodium and Azithromycin also has exhibited an -inflammatory ac vity, though much less when compared to Diclofenac sodium and Ciprofloxacin.