Modeling of Protein Interaction Networks

Alexei Vázquez, Alessandro Flammini, Amos Maritan, Alessandro Vespignani
2002 ComPlexUs  
We introduce a graph-generating model aimed at representing the evolution of protein interaction networks. The model is based on the hypothesis of evolution by duplication and divergence of the genes which produce proteins. The obtained graphs have multifractal properties recovering the absence of a characteristic connectivity as found in real data of protein interaction networks. The error tolerance of the model to random or targeted damage is in very good agreement with the behavior obtained
more » ... behavior obtained in real protein network analyses. The proposed model is a first step in the identification of the evolutionary dynamics leading to the development of protein functions and interactions.
doi:10.1159/000067642 fatcat:oiov3mq4szcn3f7lb2ueevkxuu