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Thrombolytic effect of human tissue-type plasminogen activator on a canine thrombosis model
ヒトmelanoma細胞株由来tissue‐type plasminogen activator(t‐PA)のイヌ冠動脈血栓におよぼす影響
1987
Blood & Vessel
ヒトmelanoma細胞株由来tissue‐type plasminogen activator(t‐PA)のイヌ冠動脈血栓におよぼす影響
We have examined the thrombolysic effect of human tissue-type plasminogen activator (t-PA) purfied from established human melanoma cell line and two chain urokinase (u-PA) from human urine administered intravenously and intracoronarily in a open chest-canine acute coronary thrombosis model. Two hrs after the total occlusion had been occurred, the 30 min administrations of t-PA and u-PA were initiated. Intravenous administration of t-PA in the doses of 30 X 103 IU/kg and 100 X 103 IU/kg induced
doi:10.2491/jjsth1970.18.278
fatcat:7bmioaezd5gwbcrqxye5vuhiq4