Bone metabolism in rheumatoid arthritis

J Jacobs, R De Nijs, W Lems, J Bijlsma
In active RA, bone resorption is increased and bone formation is normal or reduced in comparison to healthy controls. This uncoupling of bone formation and resorption with a negative remodelling balance leads to generalized bone loss. The pathogenesis of this altered bone metabolism is multifactorial, involving non-disease-specific factors (such as age, female sex and postmenopausal status) and disease-specific factors.