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Hutchinson-Gilford progeria syndrome
2006
Drugs of the future
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The Hutchinson-Gilford syndrome or progeria is a laminopathy generated by mutations that affect LMNA gene. This produces an abnormal protein named progerine which alters the formation of the cellular membrane inducing premature aging of all cells. In the present review aspects related to the pathophysiology and clinical characteristics of this syndrome are shown.
doi:10.1358/dof.2006.031.05.977409
fatcat:lq24c3f76bbr3jdynsftjrxgnu