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Drug Research Using Spontaneously Hypertensive Rats (SHR)
1987
Proceedings of The Japanese Association of Animal Models for Human Diseases
Preserved Fulltext
Spontaneously hypertensive rats (SHR) have been regarded as a useful animal model for human essential hypertension. In 1974, stroke-prone SHR (SHRSP) rats were successfully separated from the substrains of SHR. At the prehypertensive phase, the ability of SHR and SHRSP to excrete sodium and water was reduced. Moreover, a reduction of renal perfusion pressure at the hypertensive phase resulted in a marked decrease in sodium and water excretion in both strains of SHR.
doi:10.1538/expanim1985.3.30
fatcat:gnb2ux2ip5huxhedr3h3jyjega