Research Snippets Upregulation of the NNP-1 gene (novel nuclear protein-1, D21S2056E) in keloid by cDNA microarray and in situ hybridization An understanding of the pathophysiology of keloid can help define the most appropriate treatment. Na et al investigated expression patterns of genes in keloids and adjacent normal skins using cDNA microarray and in situ hybridization for the purpose of defining the genes involved in keloid. From this study, 9 genes in keloid tissue were distinct from the

more »

... jacent normal skin tissue. Na et al focused on NNP-1 gene, and selected to do in situ hybridization study for its specific changes. From these results, they suspected the NNP-1 gene had strongly involved in the development of keloid. Na G-Y, Seo S-K, Lee S-J et al, Upregulation of the NNP-1 (novel nuclear protein-1, D21S2056E) gene in keloid tissue determined by cDNA microarray and in situ hybridization. Br J Dermatol 2004; 151: 1143)1149.