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Argonaute 2 in dopamine 2 receptor–expressing neurons regulates cocaine addiction
2010
Journal of Cell Biology
Abbreviations used: ADCID, Argo2-dependent, induced by cocaine and DRD2-enriched; ANOVA, analysis of variance; miRNA, microRNA; MSN, medium spiny neuron; RISC, RNA-induced silencing complex; RQ, relative quantification; TH, tyrosine hydroxylase. Cocaine is a highly addictive drug that exerts its effects by increasing the levels of released dopamine in the striatum, followed by stable changes in gene transcription, mRNA translation, and metabolism within medium spiny neurons in the striatum. The
doi:10.1083/jcb1902oia4
fatcat:mgvzslwvabem3kxljynsriefcu