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FM1-43 Imaging Reveals cGMP-Dependent Long-Term Depression of Presynaptic Transmitter Release
Journal of Neuroscience
A persistent question concerning mechanisms underlying longterm, activity-dependent synaptic plasticity is whether the sites of alterations are presynaptic, postsynaptic, or both. Recently, we discovered a chemical method of inducing long-term depression (LTD) of synaptic strength at Schaffer collateral-CA1 synapses by simultaneously elevating [cGMP] and inhibiting cAMP-dependent protein kinase (PKA). Chemical LTD (CLTD) is activity-independent, occluded by stimulus-evoked LTD, and requiresdoi:10.1523/jneurosci.21-19-j0002.2001 pmid:11567078 fatcat:v4t6fdoukbbvbibhwfu3x4tlqi