Unique Pattern of Pulmonary Function after Exercise in Patients with Cystic Fibrosis

Ted. A. Kaplan, Gina Moccia, Robert M. McKey
1994 Pediatric Exercise Science  
The purpose of this study was to assess the incidence, degree, pattern, and time course of pulmonary function test (PFT) changes measured after a dynamic exercise challenge. Forced expiratory maneuvers were performed before and serially after a 7-min run-walk in 44 patients with cystic fibrosis (CF). Twenty-four patients met at least one PFT criterion for exercise-induced bronchospasm (EIB) within 21 min after exercise, and 38 patients had 25% increase in a PFT parameter at some point after
more » ... ome point after exercise. The mean time of greatest increase in PFTs occurred sooner than the greatest decrease, which was later than for 22 patients with asthma or allergic rhinitis found to have EIB. Age was inversely related to percentage fall in forced expiratory volume in 1 s (FEV,) after exercise. These results demonstrate a distinct pattern of PFTs measured after exercise in most patients with CF, with an early bronchodilation followed by a significant decrease in PFTs. Many patients with cystic fibrosis (CF) complain of shortness of breath often accompanied by coughing during or after exercise. These symptoms are also typical of exercise-induced bronchospasm (EIB), an increase in bronchial obstruction to airflow that can occur after aerobic activities (2). Studies that have attempted to quantify the incidence of EIB in patients with CF have assessed changes in pulmonary function tests (PFTs) using varying techniques. These investigations have produced conflicting results, ranging from no patients having
doi:10.1123/pes.6.3.275 fatcat:kdz6fy3o4jfqxk7bwfmc53gkey