NMDA receptor modulation and severe acute respiratory syndrome treatment

Blaise M. Costa
2021 F1000Research  
N-Methyl-D-aspartate (NMDA) subtype of glutamate receptors is expressed in the human lungs and central nervous system. NMDA receptor potentiation could increase calcium ion influx and promote downstream signaling mechanisms associated with cellular contractions that are disrupted in severe acute respiratory syndrome. Pharmacological effects generated by triggering glutamate receptor function in the brain, coupled with concurrent stimulation of the respiratory tract, may produce a synergetic
more » ... ct, improving the airway smooth muscle function. A novel multipronged intervention to simultaneously potentiate NMDA receptors expressed both in the central nervous system and airway muscles would be helpful for the treatment of severe acute respiratory syndrome that deteriorates peripheral and central nervous system function before causing death in humans.
doi:10.12688/f1000research.73897.1 pmid:36544563 pmcid:PMC9745209 fatcat:isflhkkrsvdc5ajqnxh23isjsa