A Method to Constrain Genome-Scale Models with 13C Labeling Data

Héctor García Martín, Vinay Satish Kumar, Daniel Weaver, Amit Ghosh, Victor Chubukov, Aindrila Mukhopadhyay, Adam Arkin, Jay D. Keasling, Costas D. Maranas
<span title="2015-09-17">2015</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ch57atmlprauhhbqdf7x4ytejm" style="color: black;">PLoS Computational Biology</a> </i> &nbsp;
Current limitations in quantitatively predicting biological behavior hinder our efforts to engineer biological systems to produce biofuels and other desired chemicals. Here, we present a new method for calculating metabolic fluxes, key targets in metabolic engineering, that incorporates data from 13 C labeling experiments and genome-scale models. The data from 13 OPEN ACCESS Citation: García Martín H, Kumar VS, Weaver D, Ghosh A, Chubukov V, Mukhopadhyay A, et al. (2015) A Method to Constrain
more &raquo; ... nome-Scale Models with 13 C Labeling Data. PLoS Comput Biol 11(9): e1004363.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pcbi.1004363">doi:10.1371/journal.pcbi.1004363</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26379153">pmid:26379153</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4574858/">pmcid:PMC4574858</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/s3zsay4drjbfhhuyne335uzawi">fatcat:s3zsay4drjbfhhuyne335uzawi</a> </span>
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