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A Hybrid Local Search for Simplified Protein Structure Prediction
Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms
Protein Structure Prediction based on Hydrophobic-Polar energy model essentially becomes searching for a conformation having a compact hydrophobic core at the center. The hydrophobic core minimizes the interaction energy between the amino acids of the given protein. Local search algorithms can quickly find very good conformations just by repeatedly moving from the current one to one of its "best" neighbor. However, once such a compact hydrophobic core is found, the search stagnates and spendsdoi:10.5220/0004239401580163 fatcat:crkdrgj2m5el7afxmzvbrott5y