A REVIEW OF THE FEASIBILITY AND CLINICAL APPLICATIONS OF MAGNETIC NANOPARTICLES AS CONTRAST AGENTS IN MAGNETIC RESONANCE IMAGING

Ali Yadollahpour
2016 International Journal of Pharmacy & Technology   unpublished
Applications of magnetic nanoparticles (MNPs) as Magnetic resonance imaging (MRI) contrast agent have been widely developed during recent years. MNPs have some unique featuresthat make them interesting option in biomedical applications. While almost all contrast agents for MRI affect both T 1 and T 2, the selective effects of MNPs on one of T 1 or T 2 is usually more prominent, leading to the division of these probes to contrast agents of T 1 and T 2. Among MNPs, paramagnetic NPs can affect T 1
more » ... NPs can affect T 1 relaxivity, called as T 1-weighted contrast agent, whereas super paramagnetic NPs are known as T 2-weighted contrast agent. Due to high cellular adsorption of MNPs, they can provide helpful differences between different cell types. The present study reviews the recent advances in applications of MNPs as contrast agents in MRI and focuses on the clinical applications of these techniques in different diseases.
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